Do you remember what happened on September 12, 1962? John F. Kennedy announced to the world that the United States had set itself an extraordinary goal: to land on the Moon. History tells us the rest: the Apollo 11 mission was carried out, and the moon landing occurred seven years later. Achieving this goal required new forms of collaboration between the public sector (NASA) and the private sector, along with extraordinary investments. What would happen, asks Mariana Mazzucato, if the same boldness were applied to tackle the most severe and complex problems of our time, from climate change to epidemics, from the digital divide to rising inequalities? These are enormous problems, resistant to simple solutions, that we can only solve by addressing them in a radically new way. In practice, this means creating new forms of partnership between the public and private sectors; it means rethinking how state budgets are structured to make them more explicitly oriented toward the long term; it means investing boldly on a large scale and using innovation, which has so far been employed solely to generate private profits, for social purposes. Above all, it means mobilizing our resources—material, intellectual, and financial—in a bold way, setting missions capable of inspiring and stimulating imagination. We managed to do all of this to reach the Moon. Today, we can do it again to achieve an even more ambitious goal: to improve the lives of all.